小鼠与人 BRCA1 缺陷乳腺肿瘤及乳腺癌中残余病灶的时空组织

Acknowledgements

We thank Carmen Widmer, Maurits Roorda, Diego Dibitetto and Chang He for their critical reading of the manuscript. We acknowledge the University of Geneva for providing the human samples used in this publication and sincerely thank all patient donors. We thank the Stroka lab at the University of Bern for providing the mouse antibody panel, and the IMC Platform in Bern for performing the IMC acquisitions. Moreover, we thank Georgina Lackner and Fabiana Kölliker for their technical support. We are grateful for the support of the Flow Cytometry and Cell Sorting Facility at the University of Bern in the acquisition of the scRNA-seq samples. We thank the NGS platform at the University of Bern for sequencing the scRNA-seq and ST samples. We also thank Cédric Walker for the alignment of the scRNA-seq data and Michael Berger for his assistance with the RNA velocity analysis. Finally, we thank Chang He for his help with the histopathological examination.

Funding

M.D. discloses support for the research of this work from the Swiss National Science Foundation [323530_207032]. I.L.G. discloses support for the research of this work from the Swiss National Science Foundation [PZ00P3_173959], the Ligue Genevoise contre le Cancer [#1712], and the ISREC Foundation [TANDEM_2023]. S.R. discloses support for the research of this work from the Swiss National Science Foundation [320030M_219453], the Swiss Cancer League [KFS-5519-02-2022], the European Research Council [ERC-2019-AdG-883877], and the ISREC Foundation [TANDEM_2023]. The remaining authors declare no relevant funding.

Author information

Author notes

1. These authors contributed equally: Demeter Túrós, Morgane Decollogny.

Authors and Affiliations

1. Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

Demeter Túrós,Morgane Decollogny,Anna Moyseos,Astrid Chanfon,Myriam Siffert,Joanne Bousmar&Sven Rottenberg

1. Bern Center for Precision Medicine (BCPM), Department for BioMedical Research, University of Bern, Bern, Switzerland

Demeter Túrós,Morgane Decollogny,Anna Moyseos,Joanne Bousmar&Sven Rottenberg

1. COMPATH, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

Astrid Chanfon

1. Department of Medicine and Center of Translational Research in Onco-Hematology, Faculty of Medicine, University of Geneva, Swiss Cancer Center Leman, Geneva, Switzerland

Lou Romanens&Intidhar Labidi-Galy

1. Division of Clinical Pathology, Department of Diagnostics, Hôpitaux Universitaires de Genève, Geneva, Switzerland

Jean-Christophe Tille

1. Department of Medical Oncology, Centre Leon Berard, Lyon, France

Olivier Tredan

1. CRCL UMR INSERM 1052-CNRS, 5286, Lyon, France

Olivier Tredan

1. Department of Oncology, Hôpitaux Universitaires de Genève, Geneva, Switzerland

Intidhar Labidi-Galy

1. Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Alberto Valdeolivas

Authors

1. Demeter Túrós
2. Morgane Decollogny
3. Anna Moyseos
4. Astrid Chanfon
5. Myriam Siffert
6. Joanne Bousmar
7. Lou Romanens
8. Jean-Christophe Tille
9. Olivier Tredan
10. Intidhar Labidi-Galy
11. Alberto Valdeolivas
12. Sven Rottenberg

Corresponding author

Correspondence to Sven Rottenberg.

Ethics declarations

Competing interests

A.V. is currently employed by F. Hoffmann-La Roche Ltd. The remaining authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Cite this article

Túrós, D., Decollogny, M., Moyseos, A. _et al._ Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer. _Nat Commun_ (2026). https://doi.org/10.1038/s41467-026-74125-6

Download citation

• Received: 16 May 2025

• Accepted: 29 May 2026

• Published: 11 June 2026

• DOI: https://doi.org/10.1038/s41467-026-74125-6